Okay, the protagonist of GTA V is Full-American, some tell that its also Italian-American.
The vehicles I saw in the trailer:
Shamal (Aircraft) (GTA SA Design)
Cropduster (Aircraft) (GTA SA Design)
Hydra (Aircraft) (GTA SA Design)
Skimmer (Sea Aircraft) (GTA SA Design)
Vader (Motorcycle) (GTA IV TBOGT Design)
Maverick (Helicopter) (GTA IV Design)
Police Maverick (Helicopter) (GTA IV Design)
Feltzer (Sports Coupe) (GTA IV Design)
Futo (Sedan Coupe) (GTA IV Design)
Habanero (Sports SUV) (GTA IV Design)
Jetski (Water Vehicle) (GTA VCS Design)
Landstalker (SUV) (GTA IV Design)
Premier (4-Door Sedan) (GTA IV Design)
Police Cruiser (4-Door Emergency Sedan) (GTA IV Design)
Buffalo (4-Door Muscle) (GTA IV TBOGT Design)
Ambulance (Emergency Vehicle) (GTA IV Design)
Cognoscenti (4-Door Sedan) (GTA IV Design)
Caddy (Golf Cart) (GTA IV TBOGT Design)
Stinger (Sports Car) (GTA III Design)
Huntley Sports (Sports SUV) (GTA IV Design)
Speedo (Cargo Van) (GTA IV Design)
Mesa (4x4 Car) (GTA SA Design)
Some of the cars have new design, but closely resembles from the other games.
Setting: Los Santos, San Andreas (Closely based on Los Angeles, California.)